Large bore transhepatic tracts were created in six anesthetised pigs. A per
ipheral tract (entering the gall-bladder bed) and a central tract were crea
ted in each pig. After balloon dilatation to 30 F and passage of a 30 F inn
er diameter sheath, bleeding was monitored with the sheath in place and aft
er sheath removal. Blood loss was quantified and tracts were examined micro
scopically. Peripheral tracts were shorter than central tracts (mean 1.9 ve
rsus 3.6 cm). Bleeding occurred more frequently and to a greater degree fro
m central tracts. Injury to small arteries and veins was identified microsc
opically in two tracts that bled heavily. Although significant bleeding, or
lack thereof after dilatation of large transhepatic tracts, was variable,
recommendations for large tract dilatation include: selection of a peripher
al tract route, use of a working sheath with an outside diameter not exceed
ing that of the inflated balloon, particular care to avoid loss of access a
nd not removing sheaths prematurely.