Identification of a new polymorphism in the 3 '-untranslated region of thehuman serotonin receptor 2C (5-HT2C) gene

Authors
Song, HR Gu, A Schanen, NC
Citation
Hr. Song et al., Identification of a new polymorphism in the 3 '-untranslated region of thehuman serotonin receptor 2C (5-HT2C) gene, MOL GEN MET, 66(3), 1999, pp. 224-227
Citations number
20
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND METABOLISM
ISSN journal
10967192 → ACNP
Volume
66
Issue
3
Year of publication
1999
Pages
224 - 227
Database
ISI
SICI code
1096-7192(199903)66:3<224:IOANPI>2.0.ZU;2-X
Abstract
We identified a polymorphism (2831T > G) in the 3'-untranslated region of 5 -HT2C receptor gene, approximately 100 kb from a previously reported coding sequence polymorphism, 796G > C (C23S). Allele frequencies were 0.90 (T) a nd 0.10 (G) and cosegregation analysis of the alleles at the two loci demon strated frequencies of 0.82 (GT), 0.08 (CT), 0.10 (GG), and 0 (CC). The inc reased informativity gained by analysis of both polymorphisms will prove us eful for future studies of this gene in X-linked neuropsychiatric disorders , (C) 1999 Academic Press.