Control of transcription and neurological diseases

In this article rye underline the importance of the transcriptional control of dopaminergic receptors in animal behavior. In particular, genetically m odified animals, for some retinoid receptors, show locomotor phenotypes whi ch resemble those found in dopamine receptor mutants. The finding that the dopamine D2 receptor contains in its promoter sequences that are responsive to retinoids points to a possible role of these molecules in the establish ment of neuropathological diseases.