Higher frequency of dicentrics and micronuclei in peripheral blood lymphocytes of cancer patients

Authors
Venkatachalam, P Paul, SFD Mohankumar, MN Prabhu, BK Gajendiran, N Kathiresan, A Jeevanram, RK
Citation
P. Venkatachalam et al., Higher frequency of dicentrics and micronuclei in peripheral blood lymphocytes of cancer patients, MUT RES-F M, 425(1), 1999, pp. 1-8
Citations number
27
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
ISSN journal
13861964 → ACNP
Volume
425
Issue
1
Year of publication
1999
Pages
1 - 8
Database
ISI
SICI code
1386-1964(19990310)425:1<1:HFODAM>2.0.ZU;2-C
Abstract
The presence of dicentric chromosome (DC) and micronuclei (MN) frequency in the peripheral blood lymphocytes of 25 cancer patients prior to chemo and radiotherapy and 21 healthy volunteers were studied. The overall DC and MN showed significantly higher frequency compared to those obtained in normal healthy volunteers (p < 0.0001). However, among 25 patients only 15 showed a higher frequency of DC aberration, nine patients showed the presence of m inutes (M) and seven patients showed chromatid breaks (ChB). The reasons fo r the higher frequency of aberration observed in these cancer patients are discussed in this paper. (C) 1999 Elsevier Science B.V. All rights reserved .