Synthesis of substituted benzoyl acrylic acids as potential inhibitors of phospholipase A(2)

Authors
Nuhn, P Herrmann, A Radman, R
Citation
P. Nuhn et al., Synthesis of substituted benzoyl acrylic acids as potential inhibitors of phospholipase A(2), PHARMAZIE, 54(2), 1999, pp. 93-98
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
2
Year of publication
1999
Pages
93 - 98
Database
ISI
SICI code
0031-7144(199902)54:2<93:SOSBAA>2.0.ZU;2-J
Abstract
Long chain alkylbenzenes were acylated with maleic anhydride and substitute d maleic anhydrides. The resulting benzoyl acrylic acids were tested on pho spholipase A(2). The isomeric ratio (Z/E) of the benzoyl acrylic acids was estimated by NMR spectroscopy. A few acrylic acids cyclized to hydroxybuten olids.