Three-dimensional analysis of joint motion in vivo provides a tool for
assessing the extent to which pathological conditions such as rheumat
oid arthritis affect function. Kinematic analyses using conventional s
ix-degree-of-freedom characterizations are strongly coordinate-system
dependent and require careful interpretation. An alternative method, e
xamining the motion in configuration space, permits identification of
the number of degrees of freedom used to perform the motion. Radial-ul
nar deviation movements of the wrist joint were tracked optoelectronic
ally in a group of twenty-eight volunteers with rheumatoid arthritis,
and an age- and gender-matched group of control subjects. Normal wrist
s demonstrated highly repeatable one-dimensional configuration spaces
for five cycles of hand movement. Wrists affected by rheumatoid arthri
tis displayed more disorganized and two-dimensional configuration spac
es. Two parameters from the configuration space trajectories were defi
ned to quantify the range of motion (ROM) and amount of inconsistency
or 'jitter' in the movement. Plots of jitter against ROM for the popul
ation of fifty-six subjects showed strong separation of the case and c
ontrol groups, with rheumatoid wrists displaying lower ROM and higher
jitter. These indices provide a simple means of quantifying difference
s between rheumatoid and normal wrists with minimal coordinate-system
dependence.