Current perspectives in the treatment of mood disorders

Lithium: Current research in the field of dysthymia therapy is dominated by the discovery of alternatives to lithium. Lithium remains however the gold standard, whether used alone or combination with anti-seizure drugs such a s carbamazepine, valpromide or valproate. The most recent data on lithium t herapy emphasize the need for precaution in case of pregnancy. Nay interact ions, particularly with converting enzyme inhibitors, have also been eviden ced. Finally, like beta blockers, lithium should be tapered off progressive ly over a two-month period to avoid early relapse. Other treatments: New candidate drugs such as lamotrigine offer some promis ing perspectives. For severe states, longterm electroconvulsivotherapy can be proposed. Finally, drug therapy should be integrated into a structured p sychotherapy program in order to favor the prevention of relapse and reduce the negative psychosocial consequences of mood disorders. Both the patient and close family and friends should participate in the psychotherapy; seve ral methods have been developed with promising efficacy to be confirmed by controlled studies.