Possible association between delusional disorder, somatic type and reducedregional cerebral blood flow

1. A 78-year-old female with DDST and pain disorder was treated by clomipra mine 20-100 mg/day. The hypochondriacal delusion was completely resolved, w hile the pains were partially resolved. 2. The SPECT using Xe-133 taken at. the early stage of clomipramine treatme nt when she still had hypochondriacal delusions, showed markedly reduced rC BF in the temporal and parietal lobes, with predominance on the left hemisp here. Meanwhile, the SPECT taken after resolution of the hypochondriacal de lusions showed a marked improvement in the reduced rCBF. 3. This report suggests that DDST has some association with reduced rCBF in the temporal and parietal lobes.