Af. Neuwald, The hexamerization domain of N-ethylmaleimide-sensitive factor: structuralclues to chaperone function, STRUCT F D, 7(2), 1999, pp. R19-R23
The hexameric structure of the D2 ATP-binding module of N-ethylmaleimide-se
nsitive factor (NSF), a chaperone involved in SNARE complex disassembly, wa
s recently determined. This structure and the previously determined structu
re of the DNA polymerase III delta' subunit have far-reaching biological si
gnificance because these modules are related to diverse ATPases that promot
e the assembly, disassembly and operation of various protein complexes.