Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic,renal and testicular tissue of rats

Authors
Patra, RC Swarup, D Senapati, SK
Citation
Rc. Patra et al., Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic,renal and testicular tissue of rats, VET HUM TOX, 41(2), 1999, pp. 65-67
Citations number
17
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY AND HUMAN TOXICOLOGY
ISSN journal
01456296 → ACNP
Volume
41
Issue
2
Year of publication
1999
Pages
65 - 67
Database
ISI
SICI code
0145-6296(199904)41:2<65:EOCOLP>2.0.ZU;2-M
Abstract
Daily ip administration of 0.5 mg cadmium (Cd)/kg body weight to rats for 3 mo enhanced lipid peroxidation and inhibited superoxide dismutase (SOD) ac tivity in liver, kidney and testes. Accumulation of Cd and SOD inhibition w as maximum in liver followed by kidney and testes, indicating a direct effe ct of Cd on SOD activity. This suggests a role of free radicals in causing cellular damage with long-term exposure to cadmium.