Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

We report a case of complete lymph node necrosis. No specific aetiology cou ld be determined by morphology, but a B lymphoid population and clonal rear rangement of the immunoglobulin heavy chain gene were demonstrated in immun ophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, w e suggest that immunohistochemical and gene rearrangement studies may provi de additional diagnostic information.