CLEFT-LIP AND PALATE, HYPERTELORISM, BRACHYCEPHALY, FLAT FACIAL PROFILE, AND CONGENITAL HEART-DISEASE IN 3 BROTHERS

A ''new'' syndrome was identified by McPherson and Clemens [1996: Am J Med Genet 62:58-60] in a brother and sister with bilateral cleft lip and palate, hypertelorism, flat facial profile, flat occiput, and comp lex heart defects. The brother also had a bilobed tongue and the siste r had malrotation of the intestine and bifid thumbs. We describe three brothers with similar anomalies apart from the bilobed tongue, malrot ation of the intestine, and bifid thumbs. McPherson and Clemens [1996: Am J Med Genet 62:58-60] suggested autosomal recessive inheritance. O ur observation of three affected brothers also raises the possibility of X-linked recessive inheritance. (C) 1997 Wiley-Liss, Inc.