SYNTHESIS AND DETERMINATION OF CIS OR TRANS ISOPROSTANE PRECURSORS BYA H-1-NMR NOE STUDY

Authors
RONDOT B DURAND T VIDAL JP GIRARD JP ROSSI JC
Citation
B. Rondot et al., SYNTHESIS AND DETERMINATION OF CIS OR TRANS ISOPROSTANE PRECURSORS BYA H-1-NMR NOE STUDY, Perkin transactions. 2, (8), 1995, pp. 1589-1594
Citations number
38
Categorie Soggetti
Chemistry Physical","Chemistry Inorganic & Nuclear
Journal title
Perkin transactions. 2 → ACNP
ISSN journal
03009580
Issue
8
Year of publication
1995
Pages
1589 - 1594
Database
ISI
SICI code
0300-9580(1995):8<1589:SADOCO>2.0.ZU;2-P
Abstract
Different isoprostane precursors have been synthesized from a 5-iodo-s ugar via a radical cyclization initiated by azoisobutyronitrile (AIBN) -Et(3)B. The NOE H-1 NMR experiment is a simple and efficient method f or the determination of the relative functional configuration of tetra substituted cyclopentane derivatives. Applied to chiral lactone struct ures or hydroxy esters, this method allows the determination a priori of their relative configuration.