EFFECT OF CONTINUOUS INTRAVENOUS ADMINISTRATION OF HIGH-DOSE G-CSF ONHEMATOLOGIC RECOVERY FOLLOWING AUTOLOGOUS PURGED BONE-MARROW TRANSPLANTATION

Delay in peripheral blood recovery is a common complication of autolog ous purged bone marrow transplantation. To overcome this problem, we e xamined the effect of continuous intravenous administration of high-do se G-CSF on hematologic recovery following autologous bone marrow tran splantation (auto-BMT) with purged bone marrow. Continuous intravenous administration of high dose G-CSF significantly facilitated the recov ery of platelet counts and reticulocyte counts compared to one-hour bo lus intravenous injection of the usual-dose G-CSF, although both ways of administration facilitated the recovery of leukocyte counts. The re sults showed continuous intravenous administration of high-dose G-CSF was useful to facilitate the recovery of not only leukocytes but also reticulocytes and platelets following auto-BMT with purged bone marrow in certain situations. Continuous i.v. administration of high-dose G- CSF may be one of the safest and most useful modes facilitating the he matopoietic recovery following auto-BMT with purged bone marrow.