LIPID ABNORMALITIES IN PATIENTS ON CAPD

Chronic renal failure is associated with alterations in the metabolism of lipoproteins. It is known that certain aspects of CAPD may lead to an increase of lipoprotein concentrations. We studied 71 patients wit h chronic renal failure undergoing CAPD, 48 men and 23 women with an a verage oi 25.3 months on CAPD. We analyzed: cholesterol, triglycerides , phospholipids, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol an d lipoprotein (a). We observed significant increases in triglycerides p < 0.001; VLDL-cholesterol p < 0.001; phospholipids p < 0.01 and lipo protein (a) p < 0.01, and significant decreases in HDL-cholesterol whe n p < 0.001 compared with the control group. No significant difference s was found between diabetic and non diabetic patients. We found a pos itive and significant correlation between lipoprotein (a) levels and u rinary protein loss (r = 0.41; p < 0.001). No correlation was found be tween measured parameters and residual renal function.