E-SELECTIN AND P-SELECTIN ARE NOT INVOLVED IN THE RECRUITMENT OF INFLAMMATORY CELLS ACROSS THE BLOOD-BRAIN-BARRIER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
B. Engelhardt et al., E-SELECTIN AND P-SELECTIN ARE NOT INVOLVED IN THE RECRUITMENT OF INFLAMMATORY CELLS ACROSS THE BLOOD-BRAIN-BARRIER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, Blood, 90(11), 1997, pp. 4459-4472
In experimental autoimmune encephalomyelitis (EAE) inflammatory cells
cross the endothelial blood-brain barrier (BBB) and gain access to the
central nervous system (CNS). Here we show that E-and P-selectin are
not involved in the recruitment of inflammatory cells across the BBB.
Neither expression of E-nor P-selectin is induced in BBB-forming endot
helium at any time after initiation of EAE. Some of the inflammatory c
ells present in the CNS during EAE express ligands for E-or P-selectin
. However, anti-E-and P-selectin antibodies influence neither immigrat
ion of inflammatory cells across the BBB nor the development of EAE, I
n general, suppression of E-and P-selectin expression on BBB endotheli
um is dependent on factors derived from the CNS microenvironment, eg,
astrocytes. Our results suggest that during EAE suppression of E- and
P-selectin expression on the BBB provides a CNS-specific mechanism to
reduce leukocyte recruitment into the CNS. (C) 1997 by The American So
ciety of Hematology.