Objective To assess the existence of a possible infectious factor in v
aricocele-related infertility. Methods A total of 925 seminal plasmas
from 590 infertile men with varicocele and 335 infertile patients with
out palpable varicocele were cultured for Ureaplasma urealyticum infec
tion, and routine semen analysis was made. Results The infection rate
of Ureaplasma urealyticum in seminal plasmas was 48. 22%. The asymptom
atic genital infection of Ureaplasma urealyticum was traced in 329 (55
. 76%) varicocele men and 117 (34. 93%) infertile patients without var
icocele (control group). A significant quantitative difference in the
incidence of genital Ureaplasma urealyticum infection between the vari
cocele and control group was observed (P<0. 005) and asthenozoospermia
was significantly more prevalent in the patients with varicocele than
in the other patients (P<0. 05). Conclusions Genital Ureaplasma ureal
yticum infection may play a role in varicocele-related infertility. To
prevent future infertility, men with both varicocele and genital Urea
plasma urealyticum infection may benefit from early evaluation and tre
atment.