NO ASSOCIATION BETWEEN IMMUNOHISTOCHEMICAL EXPRESSION OF P53, C-ERBB-2, KI-67, ESTROGEN AND PROGESTERONE RECEPTORS IN FEMALE PAPILLARY THYROID-CANCER AND IONIZING-RADIATION

An association has previously been reported between exposure to medica l diagnostic ionizing radiation and papillary thyroid cancer in women. To further evaluate potential mechanisms in carcinogenesis, the expre ssion of p53, c-erbB-2, as well as Ki-67, estrogen and progesterone re ceptors were analyzed by immunohistochemistry in 19 women exposed to X -rays and for comparison in nine women without such reported exposure. They all had papillary thyroid cancer. No difference was found betwee n these groups. The results of this study showed that p53, c-erbB-2, K i-67, estrogen and progesterone receptors are not involved in papillar y thyroid cancer associated with exposure to medical diagnostic ionizi ng radiation. (C) 1997 Elsevier Science Ireland Ltd.