HUMAN-PAPILLOMAVIRUS, CYTOMEGALOVIRUS AND HERPES-SIMPLEX VIRUS-INFECTIONS FOR CERVICAL-CANCER IN TAIWAN

Previously, we had reviewed 43 cases of invasive cancers, adenosquamou s cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalenc e of CMV and HSV infections from these cases of cervical carcinoma was 67 and 76%, respectively, by polymerase chain reaction. The results o f the analysis of the association of HPV, CMV and HSV with various cli nical characteristics of cervical cancer patients indicated that the c orrelation between HSV infections and clinical stages of squamous carc inoma was marginally significant (P = 0.068). HSV infections seemed to have a higher association with cell keratinization pattern as compare d with the other two viral infections. (C) 1997 Elsevier Science Irela nd Ltd.