The mechanisms of autowaves propagation through local non-homogeneitie
s in active media relevant to diverse class of physiological systems w
ere studied by means of a computer simulation. The model proposed by Z
el'dovich and Frank-Kamenetsky and that of FitzHugh-Nagumo were used f
or studying autowave tunneling, which in a broad sense implies underba
rrier passing. It was shown that for every fixed parameter value corre
sponding to the degree of non-excitability of local area a critical va
lue for non-excitable zone latitude exists. An autowave overcomes the
barrier and continues to propagate when the value of zone latitude is
less than critical. Critical conditions for origination of a source of
periodical sequence of impulses in excitable medium were found. The s
ource properties, as shown, can be modified by regulation of size of a
non-excitable zone and a zone of higher excitability. In particular,
the conditions when spatial irregularity behaves as a source of unidir
ectional and/or asynchronous sequence of impulses were explored.