COMPARATIVE CYTOTOXICITY OF CISPLATIN, SODIUM SELENITE AND SELENIUM-CISPLATIN CONJUGATE [(NH3)(2)PT(SEO3)] - CHANGES OF BLOOD-PLATELET ACTIVATION

Authors
WACHOWICZ B OLAS B
Citation
B. Wachowicz et B. Olas, COMPARATIVE CYTOTOXICITY OF CISPLATIN, SODIUM SELENITE AND SELENIUM-CISPLATIN CONJUGATE [(NH3)(2)PT(SEO3)] - CHANGES OF BLOOD-PLATELET ACTIVATION, General physiology and biophysics, 16(3), 1997, pp. 263-272
Citations number
26
Journal title
General physiology and biophysics → ACNP
ISSN journal
02315882
Volume
16
Issue
3
Year of publication
1997
Pages
263 - 272
Database
ISI
SICI code
0231-5882(1997)16:3<263:CCOCSS>2.0.ZU;2-O
Abstract
The cytotoxic effects of a novel compound, conjugate Se-Pt [(NH3)(2)Pt (SeO3)] on blood platelet function (aggregation, release of adenine n ucleotides) were studied. Contrary to the action of cisplatin or selen ite alone, [(NH3)(2)Pt(SeO3)] did not inhibit ADP-induced platelet agg regation, thrombin-induced release of adenine nucleotides from platele ts, and had no effect on the metabolism of platelet arachidonate. The tested compound seems to be less toxic than cisplatin alone, and has n o effect on blood platelet activation.