LIMITED VALUE OR ARGYOPHIL NUCLEOLAR ORGANIZER REGIONS IN THE ASSESSMENT OF ESOPHAGEAL LESIONS

Citation
Rs. Alrashed et al., LIMITED VALUE OR ARGYOPHIL NUCLEOLAR ORGANIZER REGIONS IN THE ASSESSMENT OF ESOPHAGEAL LESIONS, Saudi medical journal, 18(6), 1997, pp. 591-593
Citations number
29
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
03795284
Volume
18
Issue
6
Year of publication
1997
Pages
591 - 593
Database
ISI
SICI code
0379-5284(1997)18:6<591:LVOANO>2.0.ZU;2-D
Abstract
Objective: To determine the usefulness of the argyophil nucleolar orga nizer scores in predicting malignant or aggressive behavior in neoplas tic and non-neoplastic lesions of the esophagus. Methods: The silver s taining technique for argyophil nucleolar organizer regions was perfor med on 66 specimens of formalin fixed paraffin wax embedded esophageal biopsies: Twenty six (26) normal biopsy specimens, 4 cases of squamou s papilloma, 10 cases of well differentiated squamous cell carcinoma, 16 cases of moderately differentiated squamous cell carcinoma and 10 c ases of adenocarcinoma were studied. Results: The mean AgNOR scores an d range of values were as follows: Normal esophageal squamous epitheli um, mean 6.3 (range 4.8 to 7.4); squamous papilloma, mean 8.6 (range 6 .9 to 10.2) well differentiated squamous cell carcinoma, mean 6.0 (ran ge 4.5 to 7.7); moderately differentiated squamous cell carcinoma mean 7.2 (range 5.5 to 8.7); adenocarcinoma mean 5.8 (range 4.5 to 6.5). T he results of the different diagnostic categories were compared using the Kruskal-Wallis test but did not achieve statistical significance. Conclusion: The AgNOR scores of different esophageal lesions did not p redict aggressive behavior or malignancy.