ALTERATIONS OF INSULIN-SECRETION IN FAMIL IAL COMBINED HYPERLIPIDEMIA

Citation
Jf. Ascaso et al., ALTERATIONS OF INSULIN-SECRETION IN FAMIL IAL COMBINED HYPERLIPIDEMIA, Medicina Clinica, 108(14), 1997, pp. 530-533
Citations number
43
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
00257753
Volume
108
Issue
14
Year of publication
1997
Pages
530 - 533
Database
ISI
SICI code
0025-7753(1997)108:14<530:AOIIFI>2.0.ZU;2-4
Abstract
BACKGROUND: We have studied the abnormalities in glucose and insulin m etabolism in a group of nondiabetic subjects with familial combined hy perlipidemia (FCH) in order to ascertain the contribution of metabolic risk factors to the elevated coronary heart disease incidence observe d in FCH. PATIENTS AND METHODS: The study includes 42 non-diabetic sub jects (25 male and 17 women, mean age 49.1 +/- 9.3 years), diagnosed w ith FCH by clinical and analytical studies of the probands and first d egree relatives. Forty two control subjects of similar age, sex and bo dy weight were also studied. In both groups plasma lipids and lipoprot eins, plasma glucose and insulin basal and after oral glucose toleranc e test (OGTT) were studied. RESULTS: The mean age, BMI and the separat ion by gender was similar in the two groups. The mean systolic and dia stolic blood pressures were higher (p < 0.01) in the FCH group compare d with controls (145.4/90.1 and 131.5/76.3 mmHg, respectively). The le vels of lipids and ape B were also higher in the FCH group. The plasma glucose values were significantly higher at 30, 60, 90 and 120 minute s during OGTT and the plasma insulin at 0, 60, 90 and 120 minutes of O GTT in FCH respect to controls. The area under the curve of the secret ion of insulin was 11652.0 +/- 2281.1 and 7205.4 +/- 2289.1 pmol/l/min in FCH and controls (p < 0.01), respectively. The percentage of subje cts with basal hyperinsulinemia was 66.6% in the FCH group and 9.5% in the controls (p < 0.01); at 2 hours OGTT, 78.5% and 9.5% in FCH and c ontrols, respectively (p < 0.01). The insulin secretion was significan tly related with the plasma triglycerides levels, cholesterol bourded to very low density lipoproteins and systolic and diastolic blood pres sure. CONCLUSIONS: Hyperinsulinism is a frequent finding in non-diabet ic subjects with FCH, both with normal and abnormal glucose tolerance and could contribute to the high incidence of cardiovascular risk in t hese patients.