PREPARATION OF NOVEL UBSTITUTED-4-HYDROXY-2H-PYRAN-2-ONE-3-CARBOXAMIDES AND ESTERS VIA PALLADIUM-CATALYZED CROSS-COUPLING METHODOLOGY

Novel bstituted-4-hydroxy-2H-pyran-2-one-3-carbox-amides and eaters 1 were prepared in a 2-step procedure from known 7-chloro-2,2-dimethylpy rano[4,3-d] 1,3-dioxin-4,5-dione 2. Palladium catalyzed cross coupling methodology was employed in the key transformation of 2 to 4. The str ategy describes a significant improvement over known literature method s.