MILD AND REGIOSPECIFIC PHOSPHORYLATION OF NUCLEOSIDES

Nucleosides are reported to be conveniently phosphorylated by diphenyl phosphate previously activated with a triarylphosphine-I-2 complex. Th e reaction is characterised by mild conditions, high yields, easy work -up and purification of the final product. The activation of the phosp horylating agent, unlike Mitsunobu reaction, enables to avoid the usua l inversion of configuration at C-3'.