FUNCTIONALIZED PYRAZOLES THROUGH A FACILE ONE-POT PROCEDURE FROM N-TOSYL-N-PROPARGYL-HYDRAZINE AND ARYL IODIDES OR VINYL TRIFLATES

Authors
CACCHI S FABRIZI G CARANGIO A
Citation
S. Cacchi et al., FUNCTIONALIZED PYRAZOLES THROUGH A FACILE ONE-POT PROCEDURE FROM N-TOSYL-N-PROPARGYL-HYDRAZINE AND ARYL IODIDES OR VINYL TRIFLATES, Synlett, (8), 1997, pp. 959
Citations number
14
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
8
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):8<959:FPTAFO>2.0.ZU;2-S
Abstract
Functionalised pyrazoles have been prepared in good overall yield thro ugh a facile one-pot procedure. The synthesis includes the palladium-c atalysed coupling of the readily available N-tosyl-N-propargylhydrazin e with aryl iodides or vinyl triflates, the palladium-catalysed annula tion of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn-3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.