THE EFFECTS OF HANGE-SHASHIN-TO ON GASTRIC FUNCTION IN COMPARISON WITH SHO-SAIKO-TO

The effects of ''Hange-shashin-to (TJ-14)'' on gastric function were e xamined in comparison with ''Sho-saiko-to (TJ-9)''. Oral treatment wit h TJ-14 (125-500 mg/kg) caused dose-dependent suppression of ethanol-i nduced gastric injury, while it did not suppress gastric lesions induc ed by water-immersion stress. TJ-9 (125-500 mg/kg, p.o.) suppressed bo th water-immersion stress-induced gastric lesions and ethanol-induced gastric injury in a dose-dependent manner. Intraduodenal administratio n of TJ-14 even at 500 mg/kg did not affect gastric juice secretion, w hile TJ-9 at 125 to 500 mg/kg dose-dependently suppressed gastric juic e secretion. TJ-14 (125-500 mg/kg, p.o.) accelerated gastric emptying in normal rats and improved the delayed gastric emptying induced by Ba Cl2 in a dose-dependent manner, whereas such effect was not noted with TJ-9. Oral treatment with TJ-14 at 500 mg/kg significantly suppressed apomorphine-induced vomiting, but it did not affect copper sulfate-in duced vomiting. These results suggest that TJ-14 exhibits an anti-ulce r action (probably based on its ability to protect the gastric mucosa) , improvement of gastric emptying and an anti-emetic action. TJ-9 also showed anti-ulcer effects, probably based on its ability to suppress gastric secretion and to protect the gastric mucosa. Thus, the present study demonstrated the effectiveness of TJ-14 and TJ-9 against gastri c disease, and provided basic data which explain the differences in cl inical application between these tao kampo medicines.