CREATINE-KINASE LEVEL AND LIPID-PEROXIDATION RATE IN HUMAN SPERMATOZOA FROM PATIENTS WITH CANCER

Purpose: The present study assessed whether the poor semen quality in patients with cancer results from the inhibition of sperm maturation a s indicated by creatine kinase or from increased oxidative stress as a ssessed by lipid peroxidation of the sperm membrane. Methods: Cryopres erved semen specimens from patients with testicular (n = 10) and nonte sticular (n = 12) cancer and normal healthy donors (n = 14) were analy zed for lipid peroxidation and creatine kinase levels. Results: The le vels of creatine kinase and malonaldehyde did not differ among testicu lar or nontesticular patients with cancer or normal healthy donors. Co nclusions: Poor semen quality in testicular and nontesticular patients with cancer is not related to creatine kinase or lipid peroxidation l evels; it may be related to other factors.