2 NEW ISOCHONDODENDRINE-TYPE ALKALOIDS FROM THE ROOTS OF ANISOCYCLA-JOLLYANA

Two new isochondodendrine-type alkaloids jollyanine (5) and fastrine ( 6) have been isolated from the roots of Anisocycla jollyana together w ith nine known alkaloids, (-)-cycleanine (1), (-)-isochondodendrine (2 ), (-)-norcycleanine (3), (-)-cycleanine N-oxide (4), (+)-dehydro-1,2 apateline, (+)-O-methyl-12 cocsoline, (+)-homoaromaline, (+)-limacusin e, and (+)-limacusine-2'-beta-N-oxide. Their structures were elucidate d by a combination of chemical and spectrometric methods including H-1 -NMR, H-1-C-13 COSY, H-1-H-1 COSY, HMQC, and HMBC experiments. Compoun ds 5 and 6 represent the first isochondodendrine-type alkaloids bearin g an oxygen substituent at the 5-position.