MICROBIOLOGICAL HYDROXYLATION AT 8 INDIVIDUAL CARBON-ATOMS OF MARCFORTINE-A

Authors
LEE BH KORNIS GI CIALDELLA JI CLOTHIER MF MARSHALL VP MARTIN DG MCNALLY PL MIZSAK SA WHALEY HA WILEY VH
Citation
Bh. Lee et al., MICROBIOLOGICAL HYDROXYLATION AT 8 INDIVIDUAL CARBON-ATOMS OF MARCFORTINE-A, Journal of natural products, 60(11), 1997, pp. 1139-1142
Citations number
18
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
11
Year of publication
1997
Pages
1139 - 1142
Database
ISI
SICI code
0163-3864(1997)60:11<1139:MHA8IC>2.0.ZU;2-2
Abstract
Hydroxylation of the indole alkaloid marcfortine A (1) at carbon atoms 5, 10, 12, 14, 15, 16, and 27 was realized by various soil-derived mi croorganisms. Fission at the C-12-N bond was also observed. The struct ural elucidation of the products (2-12) was accomplished by spectrosco pic and semisynthetic means.