SANICULOSIDE N FROM SANICULA-EUROPAEA L

Extracts from the aerial parts of Sanicula europaea L. were investigat ed for their anti-HN activity, and the 50% ethanolic extract was shown to exhibit the highest activity. A new triterpene saponin glycoside, 21 -D-glucopyranosyl(1-->3)-beta-D-glucuronopyranosyl propyl ester]-3 beta,15,16,22 alpha,28 beta-pentahydroxy-Delta(12)-oleanene, saniculos ide N (1), in addition to the known phenolic acids, rosmarinic acid (2 ), and caffeic acid(3) were isolated as major components. Rosmarinic a cid was established as the principal active substance.