ANTIMYCOBACTERIAL POLYYNES OF DEVILS-CLUB (OPLOPANAX-HORRIDUS), A NORTH-AMERICAN NATIVE MEDICINAL PLANT

Authors
KOBAISY M ABRAMOWSKI Z LERMER L SAXENA G HANCOCK REW TOWERS GHN DOXSEE D STOKES RW
Citation
M. Kobaisy et al., ANTIMYCOBACTERIAL POLYYNES OF DEVILS-CLUB (OPLOPANAX-HORRIDUS), A NORTH-AMERICAN NATIVE MEDICINAL PLANT, Journal of natural products, 60(11), 1997, pp. 1210-1213
Citations number
25
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
11
Year of publication
1997
Pages
1210 - 1213
Database
ISI
SICI code
0163-3864(1997)60:11<1210:APOD(A>2.0.ZU;2-0
Abstract
Two new (3 and 5), as well as three known (1,2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae): a medicin al plant of North America. The structures were established by H-1 and C-13 NMR. The absolute configurations of 2 and 5 were determined by ap plication of Mosher's method. All the polyynes exhibited significant a nti-Candida, antibacterial, and antimycobacterial activity, with an ab ility to kill Mycobacterium tuberculosis and isoniazid-resistant Mycob acterium avium at 10 mu g/disk in a disk diffusion assay.