STIMULATION OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 PRODUCTIVITY BY THE ORAL-ADMINISTRATION OF CABBAGE JUICE TO RATS

The effect of orally administering cabbage juice on tumor necrosis fac tor alpha (TNF) and interleukin-1 (IL-1) productivity was studied in r esident peritoneal macrophages from normal and hepatoma-bearing rats. The productivity of TNF and IL-I was stimulated by gastric intubation of cabbage juice in the normal state, but not in the hepatoma-bearing state where the production of these cytokines had already been stimula ted. From these results, cabbage may contain some effective component( s) that can be absorbed from the gastrointestinal tract to stimulate t he production of TNF and IL-1.