M. Bekaroglu et al., BIPOLAR AFFECTIVE-DISORDER ASSOCIATED WITH KLINEFELTERS-SYNDROME - A CASE-REPORT, Israel journal of psychiatry and related sciences, 34(4), 1997, pp. 308-310
Several cytogenetic surveys and literature reviews have suggested a po
ssible association between Klinefelter's syndrome and bipolar illness.
We describe a manic patient with Klinefelter's syndrome who was treat
ed successfully with lithium. Our patient represents the 32nd reported
case of bipolar disorder in an individual with a known chromosomal ab
normality, the 15th with Klinefelter's syndrome, and the 11th with a k
aryotype of 47XXY.