PYRROLE BUTYRIC-ACID DERIVATIVES AS INHIBITORS OF STEROID 5-ALPHA-REDUCTASE

Authors
KATO M KOMODA K NAMERA A SAKAI Y OKADA S YAMADA A YOKOYAMA K MIGITA E MINOBE Y TANI T
Citation
M. Kato et al., PYRROLE BUTYRIC-ACID DERIVATIVES AS INHIBITORS OF STEROID 5-ALPHA-REDUCTASE, Chemical and Pharmaceutical Bulletin, 45(11), 1997, pp. 1767-1776
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
11
Year of publication
1997
Pages
1767 - 1776
Database
ISI
SICI code
0009-2363(1997)45:11<1767:PBDAIO>2.0.ZU;2-Y
Abstract
A series of pyrrole butyric acid derivatives was synthesized and evalu ated for inhibitory activity on human and rat steroid 5 alpha-reductas e in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1 -methyl-2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effec tive inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inh ibitory activities against both rat and human 5 alpha-reductase.