PREPARATION AND DISSOLUTION BEHAVIOR OF ETHENZAMIDE SOLID DISPERSIONSUSING VARIOUS SUGARS AS DISPERSION CARRIERS

Ethenzamide (ETZ) solid dispersions were prepared using the sugars suc rose, maltose, galactose and mannitol as carriers by melting and rapid cooling with liquid nitrogen, The physical chararcteristics of these solid dispersions were investigated by powder X-ray diffraction, diffe rential scanning calorimetry and dissolution rate analyses, The dissol ution rate of ETZ can be significantly increased by decreasing the cry stallinity of ETZ in solid dispersions, The maximum dissolution rate w as observed with solid dispersions containing sucrose, and X-ray diffr action analysis suggested that ETZ was present in a totally amorphous state. The physical stability of amorphous sugars in dispersions prepa red by rapid cooling was also investigated, Solid dispersions made wit h amorphous sucrose were more stable than those with other sugars, The se results indicated that amorphous sucrose is useful as a carrier for production of solid dispersions.