Close liaison between paediatric and adult endocrinologists is essenti
al for optimum care in a variety of clinical conditions. The increasin
gly recognized importance of growth hormone deficiency (GHD) in the ad
ult is a further indication for maintaining long-term follow-up of pat
ients with isolated GHD, which remains demonstrable when linear growth
is complete, in addition to those patients presenting in childhood wi
th evidence of structural pituitary disease and anterior pituitary fai
lure. Additional areas in which liaison is desirable include congenita
l adrenal hyperplasia, precocious puberty, gonadal dysgenesis and othe
r disorders of primary and secondary sexual development, thyroid dysfu
nction, diabetes mellitus, inherited neoplasia syndromes and those con
ditions, for example Gushing's syndrome, which present in childhood bu
t are more common in adult clinical endocrine practice. In this brief
review, the diagnostic spectrum of the paediatric/adult interface is d
escribed and the rationale for an integrated approach to treatment and
follow-up is outlined.