ERYTHROCYTE ADENYLATE KINASE ISOENZYME AS A MARKER FOR HEMOLYSIS

The presence in serum of adenylate kinase isoenzyme originating from e rythrocyte can be useful as a marker for detecting hemolysis. We have presented preliminary evidence for identifying hemolytic anemia patien ts earlier by determining erythrocyte AK isoenzyme activity in serum ( or plasma) rather than using measurement of plasma hemoglobin concentr ation. This test being quite specific for hemolysis should find use as a quick method for estimating the extent of in vivo hemolysis in hemo lytic patients earlier than heretofore possible. (C) 1997 Wiley-Liss, Inc.