SEQUENTIAL INJECTION METHOD FOR THE DETERMINATION OF OXPRENOLOL IN PHARMACEUTICAL PRODUCTS USING CHEMOMETRIC METHODS OF OPTIMIZATION

A sequential injection (SI) spectrophotometric method for the determin ation of oxprenolol in pharmaceutical products was developed. The meth od is based on the oxidation of oxprenolol on-line with Ce(IV) in sulf uric acid medium and the subsequent monitoring of the absorbance of th e oxidized form of the drug at 480 nm. The procedure was optimized by the orthogonal array design at two and four levels. The factors includ ed in the optimization were Ce(IV) concentration, sulfuric acid concen tration, and the stop time of the composite zone at the reaction coil. The optimized SI system with a linear dynamic ran,ae of 50-400 ppm wa s found to be suitable for the assay of oxprenolol in pharmaceutical p roducts. (C) 1997 Academic Press.