GLUTATHIONE-S-TRANSFERASE ACTIVITY AND GLUTATHIONE CONTENT IN HUMAN BLADDER-CARCINOMA ASSOCIATED WITH SCHISTOSOMIASIS - COMPARISON WITH UNINVOLVED SURROUNDING TISSUES

Authors
HASSAN AAM TAGLIABUE G CODEGONI AM DINCALCI M ELSEWEDY SM AIROLDI L
Citation
Aam. Hassan et al., GLUTATHIONE-S-TRANSFERASE ACTIVITY AND GLUTATHIONE CONTENT IN HUMAN BLADDER-CARCINOMA ASSOCIATED WITH SCHISTOSOMIASIS - COMPARISON WITH UNINVOLVED SURROUNDING TISSUES, Cancer letters, 121(1), 1997, pp. 19-23
Citations number
20
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
121
Issue
1
Year of publication
1997
Pages
19 - 23
Database
ISI
SICI code
0304-3835(1997)121:1<19:GAAGCI>2.0.ZU;2-H
Abstract
Glutathione (GSH), glutathione S-transferase (GST) activity and GST pi expression were measured in 10 human bladder tumors and adjacent unin volved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein an d GST pi expression were higher in tumor tissues (P < 0.05) than in un involved tissues. There was a positive correlation between GST activit y and GSH content and between total GST activity and GST pi expression in both tumor and uninvolved tissues. (C) 1997 Elsevier Science Irela nd.