Kh. Zavitz et Sl. Zipursky, CONTROLLING CELL-PROLIFERATION IN DIFFERENTIATING TISSUES - GENETIC-ANALYSIS OF NEGATIVE REGULATORS OF G(1)-]S-PHASE PROGRESSION, Current opinion in cell biology, 9(6), 1997, pp. 773-781
Withdrawal from the cell cycle as cells begin to differentiate is acco
mplished by the downregulation of cyclin-dependent kinase activities i
n G(1) phase. Recent analysis of loss-of-function mutations in flies,
worms, and mice has provided insight into the roles of various negativ
e regulators of G(1) phase in developing organisms.