THE METAPHASE-TO-ANAPHASE TRANSITION - AVOIDING A MIDLIFE CRISIS

Authors
COHENFIX O KOSHLAND D
Citation
O. Cohenfix et D. Koshland, THE METAPHASE-TO-ANAPHASE TRANSITION - AVOIDING A MIDLIFE CRISIS, Current opinion in cell biology, 9(6), 1997, pp. 800-806
Citations number
61
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
9
Issue
6
Year of publication
1997
Pages
800 - 806
Database
ISI
SICI code
0955-0674(1997)9:6<800:TMT-AA>2.0.ZU;2-U
Abstract
The metaphase-to-anaphase transition is a highly regulated process, wh ich is governed by the activity of the anaphase-promoting complex (APC ). The APC promotes the degradation of several proteins, including mit otic cyclins and newly identified anaphase inhibitors. Several discove ries made this year shed invaluable light on the regulation of APC act ivation and its substrate specificity.