EFFECT OF THE PROFILE OF ANTIGEN DELIVERY ON ANTIBODY-RESPONSES IN MICE

The effect of antigen delivery profiles on antibody responses were stu died by administering bovine serum albumin (BSA) to mice in various de livery profiles; continuously from mini-osmotic pumps, by injection or combinations of pumps and injections. The level and relative avidity of antibody responses were monitored for up to 40 weeks by ELISA. Cont inuous delivery of BSA stimulated equivalent levels of antibody to del ivery by injections over the same time periods (4, 8 or 12 weeks). Adm inistration of part of the antigen dose as an injection either before or after continuous delivery increased antibody levels for only a tran sient period compared to other treatments. The time period between inj ections of BSA significantly affected the levels of antibody induced.