Mm. Faas et al., ASPIRIN TREATMENT OF THE LOW-DOSE-ENDOTOXIN-TREATED PREGNANT RAT - PATHOPHYSIOLOGIC AND IMMUNOHISTOLOGIC ASPECTS, The Journal of laboratory and clinical medicine, 130(5), 1997, pp. 496-508
In the present study, we evaluated the effect of low-dose aspirin (ace
tylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin e
xcretion, glomerular fibrinogen deposits, and glomerular (basement) me
mbrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well a
s on glomerular inflammation in pregnant rats infused with low-dose en
dotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endo
toxin (ET rats) or saline (control rats) and received ASA in their dri
nking water. These rats were compared with non-ASA-treated rats. Blood
pressure and albumin excretion were measured from day 15 to day 21, a
nd glomerular fibrinogen and ecto-ADPase activity were measured at day
21. Glomerular inflammation was evaluated at various times after the
start of the infusion. The results show that treatment with ASA had a
significant beneficial effect on hypertension and inflammation induced
by endotoxin in pregnant rats, whereas it reduced albumin excretion a
nd glomerular fibrinogen deposits in some of the rats.