AZIDOTHYMIDINE, BLOCKING TELOMERASE FUNCT IONING, SHORTENS TELOMERIC REPEATS IN TRANSFORMED HUMAN-CELLS

Authors
EGOROV EE AKHMALISHEVA AK SMIRNOVA YB SHINKAREV DB CHERNOV DN ZELENIN AV KRAEVSKII AA
Citation
Ee. Egorov et al., AZIDOTHYMIDINE, BLOCKING TELOMERASE FUNCT IONING, SHORTENS TELOMERIC REPEATS IN TRANSFORMED HUMAN-CELLS, Genetika, 33(10), 1997, pp. 1444-1446
Citations number
23
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
33
Issue
10
Year of publication
1997
Pages
1444 - 1446
Database
ISI
SICI code
0016-6758(1997)33:10<1444:ABTFIS>2.0.ZU;2-G
Abstract
The long-term action of azidothymidine, reverse transcriptase inhibito r, an cultivated U-937 (human promyelocyte leukemia) and MeWo (human m elanoma) cells led to the concentration-dependent decrease in the leng th of telomeric chromosomal repeats, Telomere shortening was accompani ed by temporary retardation of cell proliferation. Combined with the d ata obtained previously, these results suggest that azidothymidine inh ibits telomerase functioning in cultivated cells.