The review deals with methods of synthesis of deuterium labelled hydro
phobic and hydrophilic synthones of lipid molecules as well as techniq
ues designed to obtain selectively and fully deuterated phospholipids
and their analogues. Deuterium labelled lipids are used, to study the
structural organisation and functioning of biological membranes includ
ing NMR and neutron diffraction studies of lipid-lipid and lipid-prote
in interactions.