CYMBIMICIN-A AND CYMBIMICIN-B, 2 NOVEL CYCLOPHILIN-BINDING STRUCTURESISOLATED FROM ACTINOMYCETES

Two novel metabolites, cymbimicins A and B, were isolated from the cul ture broth of a strain of Micromonospora sp. by screening for cyclophi lin binding metabolites from actinomycete strains. Cymbimicin A binds to cyclophilin A with a high affinity six fold lower than to that of c yclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fermentation, isolation, physical and biological properties and structure elucidation are descr ibed.