HYDROXYAKALONE, A NOVEL XANTHINE-OXIDASE INHIBITOR PRODUCED BY A MARINE BACTERIUM, AGROBACTERIUM-AURANTIACUM

Authors
IZUMIDA H ADACHI K MIHARA A YASUZAWA T SANO H
Citation
H. Izumida et al., HYDROXYAKALONE, A NOVEL XANTHINE-OXIDASE INHIBITOR PRODUCED BY A MARINE BACTERIUM, AGROBACTERIUM-AURANTIACUM, Journal of antibiotics, 50(11), 1997, pp. 916-918
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
11
Year of publication
1997
Pages
916 - 918
Database
ISI
SICI code
0021-8820(1997)50:11<916:HANXIP>2.0.ZU;2-M
Abstract
A new xanthine oxidase inhibitor named hydroxyakalone was isolated fro m the culture broth of a marine bacterium Agrobacterium aurantiacum N- 81106. Structure of hydroxyakalone was determined to be 4-amino-1H-pyr azole[3,4-d]pyrimidine-3-one-6-ol by the spectral studies of hydroxyak alone and its permethyl derivative. The concentration to induce 50% in hibition (IC50) was 4.6 mu M against xanthine oxidase.