HUMAN ANGIOSTATIN INHIBITS MURINE HEMANGIOENDOTHELIOMA TUMOR-GROWTH IN-VIVO

Angiostatin inhibits angiogenesis and metastatic tumor growth; however , its usefulness in treating primary nonmetastasizing tumors is less w ell understood, We now report the effectiveness of human angiostatin a dministration in a mouse hemangioendothelioma model. Human angiostatin was administered to mice with s,c, hemangioendothelioma and associate d disseminated intravascular coagulopathy (Kasabach-Merritt syndrome). Angiostatin significantly reduced tumor volume in comparison to nontr eated controls, increased survival, and prevented the profound thrombo cytopenia and anemia of Kasabach-Merritt syndrome, Apoptosis of tumor cells was induced by angiostatin, but tumor cell proliferation was not inhibited, These data suggest angiostatin as a novel treatment for no nmetastasizing vascular tumors and for Kasabach-Merritt syndrome.