THE ROLE OF COMPLEMENT, ANTIBODY, AND TUMOR-NECROSIS-FACTOR-ALPHA IN THE KILLING OF PLASMODIUM-FALCIPARUM BY THE MONOCYTIC CELL-LINE THP-1

Authors
KUMARATILAKE LM FERRANTE A JAEGER T MORRISJONES SD
Citation
Lm. Kumaratilake et al., THE ROLE OF COMPLEMENT, ANTIBODY, AND TUMOR-NECROSIS-FACTOR-ALPHA IN THE KILLING OF PLASMODIUM-FALCIPARUM BY THE MONOCYTIC CELL-LINE THP-1, Infection and immunity, 65(12), 1997, pp. 5342-5345
Citations number
12
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
12
Year of publication
1997
Pages
5342 - 5345
Database
ISI
SICI code
0019-9567(1997)65:12<5342:TROCAA>2.0.ZU;2-I
Abstract
Killing of Plasmodium falciparum blood forms by the differentiated hum an myelomonocytic THP-1Mo cell line was studied by a radiometric assay . Results showed that parasite killing was promoted by complement, ant imalarial antibody, and the cytokines tumor necrosis factor alpha and gamma interferon. Differentiated THP-1Mo appears to be a useful monocy tic cell line for the study of mechanisms of immunity to Plasmodium.